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Article Dans Une Revue Marine drugs Année : 2023

Bioactive Oxylipins Profile in Marine Microalgae

Rémi Pradelles
  • Fonction : Auteur


Microalgae are photosynthetic microscopic organisms that serve as the primary food source in aquatic environments. Microalgae can synthesize a wide variety of molecules, such as polyunsaturated fatty acids (PUFAs) of the omega-3 and omega-6 series. Oxidative degradation of PUFA due to radical and/or enzymatic conversion leads to the formation of oxylipins, which are compounds known for their bioactive properties. In the present study, we aim to profile oxylipins from five microalgae species grown in 10-L photo-bioreactors under optimal conditions. During their exponential phase, microalgae were harvested, extracted and analyzed by LC-MS/MS to determine the qualitative and quantitative profile of oxylipins for each species. The five different selected microalgae revealed a high diversity of metabolites, up to 33 non-enzymatic and 24 enzymatic oxylipins present in different concentrations. Taken together, these findings highlight an interesting role of marine microalgae as a source of bioactive lipids mediators, which we hypothesize have an important function in preventive health measures such as amelioration of inflammation. The rich mixture of oxylipins may display advantages to biological organisms, especially by providing for human health benefits including antioxidant, anti-inflammatory, neuroprotective or immunomodulator activities. Some oxylipins are also well known for their cardiovascular properties.
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hal-04007466 , version 1 (28-02-2023)




Amandyne Linares-Maurizi, Guillaume Reversat, Rana Awad, Valérie Bultel-Poncé, Camille Oger, et al.. Bioactive Oxylipins Profile in Marine Microalgae. Marine drugs, 2023, 21 (3), pp.136. ⟨10.3390/md21030136⟩. ⟨hal-04007466⟩
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