Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data
Abstract
Our meta-analysis of rodent studies firmly establishes that intermittent hypoxia, as a model of obstructive sleep apnea, alters brain inflammation, oxidative stress and apoptosis. Severity of IH and brain localization contribute to this impact.
Our work shows that for several parameters, the impact of IH varies with IH severity and brain localization. More studies are needed to gain a more comprehensive view of the IH impact, including various IH severities and durations and their specific impact on different brain regions. The vast majorities of studies are performed in male rodents, studies including female rodent are thus mandatory to understand sex-related variability of IH impact. Finally, IH is predominantly used as a model to mimic OSA in rodents, and the impact of sleep fragmentation on the rodent brains remains an under-investigated issue.
Given the important consequences of intermittent hypoxia on the brain, our work also strongly support the interest of identifying and treating sleep apnea in neurology practice.
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